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Exposure towards the glucuronide metabolite is 35 to 40 occasions higher than exposure for the father or mother drug. In vitro knowledge propose that hydromorphone in clinically pertinent concentrations has minimum prospective to inhibit the exercise of human hepatic CYP450 enzymes including CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.There may be new in